Polynucleotide injections in London. The treatment people call salmon sperm.

Yes. Polynucleotides are purified DNA fragments (PDRN) derived from salmon or trout milt, which is where the nickname comes from. The material is purified to remove protein before it is used, so nothing living is injected and it is not sperm in any meaningful sense. You may also see it called salmon DNA, PDRN, or a brand name such as Nucleofill. It is a biostimulator rather than a filler, so it changes skin quality rather than adding volume, and results build over a course. Individual results vary.

At Melatone, Nucleofill Eyes for the under-eye area is a Course of 3 at £540 (£180 per session, three sessions four weeks apart per the published protocol), or £200 for a single session. Nucleofill Strong for the full face is £200 a session, with the course price confirmed at your consultation. A £30 consultation is deducted from your first treatment.

You can book polynucleotides at Melatone Skin Clinic in Battersea SW11, 10 to 14 minutes on foot from Clapham Junction and serving Clapham and South West London. Nucleofill polynucleotides are delivered by Arman Zaki, our founder and GMC-registered Physician Associate. Book a consultation online, or message us on WhatsApp at +44 7586 817215 to arrange it.

Arman Zaki, our GMC-registered Physician Associate. He is trained in regenerative skin therapy and delivers Nucleofill polynucleotides.

Yes, when delivered by a clinician experienced in melanated skin, polynucleotide injectables are generally well tolerated across Fitzpatrick skin types IV, V and VI. Because they are not a light-based treatment, they do not carry the wavelength-related risks that laser can pose for deeper skin tones. The main consideration in pigmented skin is post-inflammatory hyperpigmentation (PIH), which the literature identifies as the key parameter to manage. We minimise that risk with conservative injection technique, fewer passes, needle depth calibrated to each zone, a Fitzpatrick assessment at consultation, and a healing-response check at follow-up. We are honest about the evidence: there is strong category-level research on polynucleotides, but no large product-specific trial dedicated to melanated skin, so we lead with cautious technique and careful patient selection rather than overclaiming. Polynucleotides are not suitable for everyone, and individual results and suitability vary. If your main concern is existing pigmentation such as melasma, we will tell you honestly at consultation whether polynucleotides, another treatment, or none is the right fit.

10 to 14 minutes on foot from Clapham Junction, or a short bus down Lavender Hill. South side of Lavender Hill at the junction with Latchmere Road, Battersea Business Centre, SW11 5QL. Battersea Park station is also nearby.

Different mechanisms. Filler adds volume by physical displacement. Polynucleotides stimulate your own fibroblasts to improve skin quality over weeks. They are complementary, not interchangeable. We will tell you which one fits your goal at consultation.

Two peer-reviewed studies we cite: a 2025 systematic review of polynucleotides in esthetic medicine (Lampridou and colleagues, Journal of Cosmetic Dermatology, PubMed 39645667), which found nine studies of low to moderate quality and called for more rigorous trials, and a 2022 randomised split-face trial of polynucleotide injections around the eyes (Lee and colleagues, Journal of Dermatological Treatment, PubMed 32248707). Neither used Nucleofill itself, so the evidence is for polynucleotides as a category. This page is general information, not a substitute for a consultation.

Downtime is minimal. Expect small raised blebs at the injection points that settle within about a day, and occasional short-lived swelling or bruising. Most people return to work the same day. Arman gives you written aftercare at the end of each session.

Most patients notice skin texture and hydration improvement after the second session. Full result typically peaks 8 to 12 weeks after the third session. Maintenance every 6 to 9 months.

Polynucleotides (Nucleofill) stimulate your own fibroblasts, the cells that build collagen and elastin. Over a course they improve skin quality, texture, hydration and firmness, and are widely used around the eyes. Results build over weeks and vary between individuals.

Melatone Skin Clinic offers polynucleotide (Nucleofill) injections at its clinic in Battersea, London SW11, delivered by Arman Zaki, GMC-registered Physician Associate, after a consultation. A single session is £200 and a Nucleofill Eyes course of 3 is £540. The clinic is a 10 to 14 minute walk from Clapham Junction and treats patients from across London.

They work differently. Polynucleotides (Nucleofill) prompt your own fibroblasts to repair and rebuild, so they suit skin quality, texture and under-eye concerns. Profhilo is a hyaluronic acid bio-remodelling treatment that hydrates and firms. They are complementary, and we advise which fits your goal at consultation.

Polynucleotides are purified fragments of DNA, in Nucleofill's case from salmon, injected into the dermis to signal your own fibroblasts to improve skin quality over weeks. They hold water as a scaffold for an early smoothing effect and calm oxidative load in the tissue. They are a biostimulator, not a filler: they do not add volume.

The published evidence, indexed on PubMed, supports improvement in the appearance of skin quality, hydration and texture over a course, and we link the studies on this page. They work gradually, through your own skin, so the change is progressive rather than instant, and individual results vary. We are honest at consultation about what they can and cannot do for your concern.

Results build over the course and are typically judged at about three months after the last session. How long they hold varies with age, skin and lifestyle; many people repeat a maintenance session or a short course six to twelve months later. We advise at your review rather than sell a schedule in advance.

For skin quality, texture and the under-eye area, where volume is not the problem, they are one of the better-evidenced regenerative options and they are suitable for all skin types, including Fitzpatrick V to VI. They are not worth it if what you want is volume or a lift, and we will tell you that at the £30 consultation rather than take a course booking.